ABCMdb

PMID: 9835492

Franz R, Kelly SL, Lamb DC, Kelly DE, Ruhnke M, Morschhauser J
Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains.
Antimicrob Agents Chemother. 1998 Dec;42(12):3065-72., [PubMed]

Sentences

No. Mutations Sentence Comment

198 ABCB1 p.Arg467Lys In that case, an R467K amino acid substitution was found in both ERG11 alleles from the isolate with elevated resistance which was not present in the previous isolates and must therefore have occurred in an intermediate isolate not recovered from the patient. Login to comment 200 ABCB1 p.Arg467Lys The G464S mutation, which is located in the heme binding domain of the Erg11p protein near the R467K substitution described by White (38), must have been introduced into one ERG11 allele before conversion to homozygosity. Login to comment