ABCMdb

PMID: 9774148

Spitaler M, Utz I, Hilbe W, Hofmann J, Grunicke HH
PKC-independent modulation of multidrug resistance in cells with mutant (V185) but not wild-type (G185) P-glycoprotein by bryostatin 1.
Biochem Pharmacol. 1998 Oct 1;56(7):861-9., [PubMed]

Sentences

No. Mutations Sentence Comment

29 ABCB1 p.Gly185Val Tel. 0043-512-507-3505; FAX 0043-512-507-2872; E-mail: johann.hofmann@uibk.ac.at &#a7; Abbreviations: HeLa-WT, drug-sensitive HeLa wild-type cells; HeLa-MDR1-G185, multidrug-resistant HeLa cells transfected with a wild-type MDR1 gene; HeLa-MDR1-V185, multidrug-resistant HeLa cells transfected with a mutant MDR1 gene (valine instead of glycine in position 185); MDR, multidrug resistance; MDR1, multidrug resistance gene 1; PGP, P-glycoprotein; PKC, protein kinase C; and TPA, 12-O-tetradecanoylphorbol-13-acetate. Login to comment 30 ABCB1 p.Gly185Val 0043-512-507-3505; FAX 0043-512-507-2872; E-mail: johann.hofmann@uibk.ac.at § Abbreviations: HeLa-WT, drug-sensitive HeLa wild-type cells; HeLa- MDR1-G185, multidrug-resistant HeLa cells transfected with a wild-type MDR1 gene; HeLa-MDR1-V185, multidrug-resistant HeLa cells transfected with a mutant MDR1 gene (valine instead of glycine in position 185); MDR, multidrug resistance; MDR1, multidrug resistance gene 1; PGP, P-glycoprotein; PKC, protein kinase C; and TPA, 12-O-tetradecanoylphorbol-13-acetate. Login to comment 98 ABCB1 p.Gly185Val It has been reported that KB-C1 cells harbor a mutated MDR1 gene in which glycine at position 185 is replaced by valine [37]. Login to comment