PMID: 9738009

Vasudevan S, Tsuruo T, Rose DR
Mode of binding of anti-P-glycoprotein antibody MRK-16 to its antigen. A crystallographic and molecular modeling study.
J Biol Chem. 1998 Sep 25;273(39):25413-9., 1998-09-25 [PubMed]
Sentences
No. Mutations Sentence Comment
201 ABCB1 p.Asp744Pro
X
ABCB1 p.Asp744Pro 9738009:201:151
status: NEW
view ABCB1 p.Asp744Pro details
 An alteration of Glu-746 to Lys, as seen in hamster class II Pgp (Table I), would clearly disrupt the interaction with Arg-H97, as would the change of Asp-744 to Pro. Login to comment 203 ABCB1 p.Asp743Arg
X
ABCB1 p.Asp743Arg 9738009:203:28
status: NEW
view ABCB1 p.Asp743Arg details
 The proposed interaction of Asp-743 with Arg-L96 would explain the lack of tolerance of an alteration of position 743 to Thr or Gly. Login to comment