ABCMdb

PMID: 9724814

Naren AP, Quick MW, Collawn JF, Nelson DJ, Kirk KL
Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein-protein interactions.
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10972-7., 1998-09-01 [PubMed]

Sentences

No. Mutations Sentence Comment

136 ABCC7 p.Gly551Asp ABCC7 p.Arg117His Those CFTR mutants that produce full-length translation products can be classified into three categories (2): (i) ER processing mutants that inefficiently traffic to the Golgi apparatus (e.g., the most common allele, ⌬F508); (ii) regulation mutants that mature normally but are refractory to activation by ATP (e.g., G551D); and (iii) conduction mutants that also mature normally but exhibit reduced single-channel conductances (e.g., R117H). Login to comment 178 ABCC7 p.Gly551Asp The efficiency of binding of band B (i.e., binding normalized to the IP signal) at 0.13 ␮M syn1A⌬C was 38.4%, 36.1%, and 5.7% for wild-type CFTR, G551D CFTR, and ⌬F508 CFTR, respectively. Login to comment