ABCMdb

PMID: 9691989

Tebbutt SJ, Lakeman MB, Wilson-Wheeler JC, Hill DF
Genetic variation within the ovine cystic fibrosis transmembrane conductance regulator gene.
Mutat Res. 1998 May;382(3-4):93-8., [PubMed]

Sentences

No. Mutations Sentence Comment

7 ABCC7 p.Arg297Gln In addition to the mutation R297Q reported previously, we have found several interesting variants, including intronic DNA variants and exonic polymorphisms. Login to comment 93 ABCC7 p.Arg297Gln d; R297Q mutation reported previously 14 . Login to comment 129 ABCC7 p.Arg297Gln w x CF-causing mutation R297Q found in humans 19 w x and has previously been reported by our group 14 . Login to comment 130 ABCC7 p.Arg297Gln ABCC7 p.Arg297Gln R297Q has since been found in two other ewes and all these animals have been involved in an embryo transfer programme in order to increase the number of animals carrying R297Q. Login to comment 131 ABCC7 p.Arg297Gln Several carrier ewes as well as a carrier ram have subsequently been generated, and will be mated in order to produce a lamb homozygous for R297Q. Login to comment 141 ABCC7 p.Arg297Gln Apart from the R297Q mutation, none of the ovine CFTR variants have equivalents in the human CFTR d; . Login to comment