PMID: 9616231

DiMango E, Ratner AJ, Bryan R, Tabibi S, Prince A
Activation of NF-kappaB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells.
J Clin Invest. 1998 Jun 1;101(11):2598-605., 1998-06-01 [PubMed]
Sentences
No. Mutations Sentence Comment
6 ABCC7 p.Trp1282*
X
ABCC7 p.Trp1282* 9616231:6:111
status: NEW
view ABCC7 p.Trp1282* details
 IB3 cells, which express mutations in cystic fibrosis transmembrane conductance regulator (CFTR) (⌬F508/W1282X), were noted to have significantly greater amounts of endogenous nuclear NF-␬B, but not the transcription factor C/EBP, than CF cells corrected by episomal copies of normal CFTR (C-38) or IB3 cells grown at a permissive temperature (25ЊC). Login to comment 44 ABCC7 p.Trp1282*
X
ABCC7 p.Trp1282* 9616231:44:126
status: NEW
view ABCC7 p.Trp1282* details
 IB3 cells, an adeno-associated virus-transformed human bronchial epithelial cell line derived from a CF patient (⌬F508/W1282X), and C-38 cells, the rescued cell line which expresses a plasmid encoded copy of a functional CFTR, obtained from P. Zeitlin (Johns Hopkins University, Baltimore, MD) (25), were grown in LHC-8 media (Biofluids, Rockville, MD) supplemented with 10% FBS. Login to comment