PMID: 9511934

Brown CR, Hong-Brown LQ, Welch WJ
Strategies for correcting the delta F508 CFTR protein-folding defect.
J Bioenerg Biomembr. 1997 Oct;29(5):491-502., [PubMed]
Sentences
No. Mutations Sentence Comment
37 ABCC7 p.Arg553*
X
ABCC7 p.Arg553* 9511934:37:122
status: NEW
view ABCC7 p.Arg553* details
ABCC7 p.Gly542*
X
ABCC7 p.Gly542* 9511934:37:112
status: NEW
view ABCC7 p.Gly542* details
 Howard and his colleagues have shown that treatment of cells expressing some of these truncation mutants (e.g., G542X and R553X) with different aminoglycoside antibiotics results in "translational read-through" and the production of low levels of a full-length and functional CFTR protein (Howard et al., 1996). Login to comment