ABCMdb

PMID: 9508799

Bond TD, Valverde MA, Higgins CF
Protein kinase C phosphorylation disengages human and mouse-1a P-glycoproteins from influencing the rate of activation of swelling-activated chloride currents.
J Physiol. 1998 Apr 15;508 ( Pt 2):333-40., 1998-04-15 [PubMed]

Sentences

No. Mutations Sentence Comment

13 ABCB1 p.Gly185Val In contrast, pretreatment with TPA reduced ICl(swell) in MDR1(G185V)-expressing transfected NIH3T3 fibroblasts. Login to comment 34 ABCB1 p.Gly185Val ABCB1 p.Gly185Val NIH3T3-MDR1(G185V) cells are NIH3T3 fibroblasts permanently transfected with human MDR1 cDNA containing the G185V mutation which increases the relative resistance to colchicine (Pastan, Gottesman, Ueda, Lovelace, Rutherford & Willingham, 1988). Login to comment 59 ABCB1 p.Gly185Val In simultaneous experiments, TPA reduced ICl(swell) in NIH3T3-MDR1(G185V) cells (P = 0·007; Fig. 2A), as reported previously. Login to comment 60 ABCB1 p.Gly185Val It should be noted that the G185V mutation in MDR1 does not influence its ability to modulate channel activation. Login to comment