ABCMdb

PMID: 9388243

Chang XB, Hou YX, Riordan JR
ATPase activity of purified multidrug resistance-associated protein.
J Biol Chem. 1997 Dec 5;272(49):30962-8., [PubMed]

Sentences

No. Mutations Sentence Comment

91 ABCC1 p.Leu370Val ABCC1 p.Asp696Gly ABCC1 p.Leu80Val These differences and the resulting amino acid changes are as follows: Thr434 to Gly (L80V), Cys546 to Thr (T117M), Cys1304 to Gly (L370V), Thr1880 to Cys (L582L), Thr2250 to Cys (L685S), Ala2283 to Gly (D696G), Cys4040 to Gly and Gly4041 to Cys (R1282A), and Gly4732 to Ala (S1512S). Login to comment 93 ABCC1 p.Leu370Val ABCC1 p.Asp696Gly ABCC1 p.Leu80Val These differences and the resulting amino acid changes are as follows: Thr434 to Gly (L80V), Cys546 to Thr (T117M), Cys1304 to Gly (L370V), Thr1880 to Cys (L582L), Thr2250 to Cys (L685S), Ala2283 to Gly (D696G), Cys4040 to Gly and Gly4041 to Cys (R1282A), and Gly4732 to Ala (S1512S). Login to comment 95 ABCC1 p.Leu80Val The first two, L80V and T117M fall within the 220-residue N- FIG. 1. Login to comment 97 ABCC1 p.Leu80Val The first two, L80V and T117M fall within the 220-residue N- FIG. 1. Login to comment 103 ABCC1 p.Leu370Val L370V represents a conservative hydrophobic replacement in TM2 of the currently favored topology model (31). Login to comment 105 ABCC1 p.Leu370Val ABCC1 p.Asp696Gly L370V represents a conservative hydrophobic replacement in TM2 of the currently favored topology model (31). Login to comment 107 ABCC1 p.Asp696Gly Similarly, an acidic residue is sometimes present in these other molecules at the position comparable with the D696G change. Login to comment