PMID: 9371774

Mechetner EB, Schott B, Morse BS, Stein WD, Druley T, Davis KA, Tsuruo T, Roninson IB
P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity.
Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12908-13., 1997-11-25 [PubMed]
Sentences
No. Mutations Sentence Comment
22 ABCB1 p.Lys1076Met
X
ABCB1 p.Lys1076Met 9371774:22:43
status: NEW
view ABCB1 p.Lys1076Met details
ABCB1 p.Lys433Met
X
ABCB1 p.Lys433Met 9371774:22:24
status: NEW
view ABCB1 p.Lys433Met details
ABCB1 p.Gln1280Ala
X
ABCB1 p.Gln1280Ala 9371774:22:137
status: NEW
view ABCB1 p.Gln1280Ala details
 The mutant Pgps contain K433M and͞or K1076M substitutions in the Walker A motifs; in addition, the cloning procedure resulted in a Q1280A substitution of the C-terminal amino acid in all of the transfected MDR1 cDNA sequences. Login to comment 185 ABCB1 p.Gly185Val
X
ABCB1 p.Gly185Val 9371774:185:243
status: NEW
view ABCB1 p.Gly185Val details
 On the other hand, these three compounds also differ from the other Pgp-transported drugs in some sterical aspect of their interaction with Pgp, because the ability of Pgp to transport these three drugs is selectively increased by a mutation (G185V) which, at the same time, decreases the Pgp activity toward those drugs that were found in the present study to increase UIC2 reactivity (36). Login to comment