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PMID: 8820951
Fine RL, Chambers TC, Sachs CW
P-glycoprotein, multidrug resistance and protein kinase C.
Stem Cells. 1996 Jan;14(1):47-55.,
[PubMed]
Sentences
No.
Mutations
Sentence
Comment
97
ABCB1 p.Ser671Asn
X
ABCB1 p.Ser671Asn 8820951:97:12
status:
NEW
view ABCB1 p.Ser671Asn details
Mutation of
serine 671 to asparagine
in the linker region of P-glycoprotein abrogated verapamil and PKC-α-stimulated ATPase activity.
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142
ABCB1 p.Gly185Val
X
ABCB1 p.Gly185Val 8820951:142:61
status:
NEW
view ABCB1 p.Gly185Val details
The human MDR1 P-glycoprotein, with a mutation of amino acid
glycine 185 to valine
, was also expressed in Sf9 cells and used as membrane vesicles.
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