PMID: 8631756

Ma J, Tasch JE, Tao T, Zhao J, Xie J, Drumm ML, Davis PB
Phosphorylation-dependent block of cystic fibrosis transmembrane conductance regulator chloride channel by exogenous R domain protein.
J Biol Chem. 1996 Mar 29;271(13):7351-6., [PubMed]
Sentences
No. Mutations Sentence Comment
159 ABCC7 p.Ser660Ala
X
ABCC7 p.Ser660Ala 8631756:159:23
status: NEW
view ABCC7 p.Ser660Ala details
 However, CFTR⌬R-S660A, a molecule with amino acids 708-835 deleted (to render it constitutively open) with the remaining consensus PKA site mutated, is insensitive to activation by PKA (9), suggesting that activation by phosphorylation takes place in the R domain. Login to comment