PMID: 8172879

Kajiji S, Dreslin JA, Grizzuti K, Gros P
Structurally distinct MDR modulators show specific patterns of reversal against P-glycoproteins bearing unique mutations at serine939/941.
Biochemistry. 1994 May 3;33(17):5041-8., [PubMed]
Sentences
No. Mutations Sentence Comment
52 ABCB4 p.Phe941Ser
X
ABCB4 p.Phe941Ser 8172879:52:192
status: NEW
view ABCB4 p.Phe941Ser details
 Chinese hamster LR73 ovary cells and their drug resistant clonal derivatives transfected with wild-type mdrl (1s) or mdr3 (3s) cDNAs or with mutant mdrl(1F) or mdr3 (3F) cDNAsbearing a single Ser to Phe substitution at position 941 (mdrl) or 939 (mdr3) in the predicted TMl 1 (Gros et al., 1991) were maintained in Dulbecco`s modified Eagle medium (D-MEM) supplemented with 10%fetal calf serum (FCS), penicillin (50units/ mL), streptomycin (100 pg/mL), and gentamycin (25 pg/ mL). Login to comment