PMID: 7985758

Peel SA, Bright P, Yount B, Handy J, Baric RS
A strong association between mefloquine and halofantrine resistance and amplification, overexpression, and mutation in the P-glycoprotein gene homolog (pfmdr) of Plasmodium falciparum in vitro.
Am J Trop Med Hyg. 1994 Nov;51(5):648-58., [PubMed]
Sentences
No. Mutations Sentence Comment
130 ABCB1 p.Gly185Val
X
ABCB1 p.Gly185Val 7985758:130:136
status: NEW
view ABCB1 p.Gly185Val details
 Cross-resistance in human KB carci noma cells was found to result from a cluster of point mutations in the MDRI gene that resulted in a Gly-185 to Val-l85 substitution in the P glycoprotein.38 The mutations were identified in a cell line where the wild-type MDR1 was am plified, yet selection for the next level of resis tance resulted in all amplified copies of the gene carrying the same mutations.39 While the IC@ of chloroquine has decreased in Mef 2.4, the par asite remains resistant to chloroquine, suggest ing that either 86-Tyr is not critical for resis tance, or that the 86-Phe change remains a competent allele for chloroquine resistance. Login to comment