PMID: 7915139

Ahmad S, Safa AR, Glazer RI
Modulation of P-glycoprotein by protein kinase C alpha in a baculovirus expression system.
Biochemistry. 1994 Aug 30;33(34):10313-8., 1994-08-30 [PubMed]
Sentences
No. Mutations Sentence Comment
112 ABCB1 p.Ser671Asn
X
ABCB1 p.Ser671Asn 7915139:112:93
status: NEW
view ABCB1 p.Ser671Asn details
 To directly determine the dependence of PGP ATPase activity on PKC-mediated phosphorylation, Ser671 was mutated to Asn within a PKC consensus phosphorylation sequence in the linker region of PGP (Figure 6). Login to comment 117 ABCB1 p.Ser671Asn
X
ABCB1 p.Ser671Asn 7915139:117:0
status: NEW
view ABCB1 p.Ser671Asn details
 Ser671Asn mutant exhibiteda similarlevelof ATPaseactivity as wild-type PGP; however,mutant PGP was resistant to the stimulatoryeffectof PKCa on ATPaseactivity, and exhibited an attenuated response to verapamil compared to wild-type PGP. Login to comment