ABCMdb

PMID: 7910372

Stein WD, Cardarelli C, Pastan I, Gottesman MM
Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates.
Mol Pharmacol. 1994 Apr;45(4):763-72., [PubMed]

Sentences

No. Mutations Sentence Comment

166 ABCB1 p.Gly185Val GLY 185 VAL 185 1.4 . Login to comment 223 ABCB1 p.Gly185Val 7. tution of valine for glycine at position 185 along the polypeptide chain of P-glycoprotein might be interpreted as having a positive effect on the ability of the mutant to extract colchicine but a negative effect on its ability to extract vinblastine from the outer half of the membrane bilayer. Login to comment 227 ABCB1 p.Gly185Val The finding that there is little effect of this mutation on the ability of the pump to handle daunorubicin is consistent with our conclusion that it is the process by which drugs enter the cell that is solely affected by the Gly-185 to Val-185 mutation. Login to comment