PMID: 7866993

Cardarelli CO, Aksentijevich I, Pastan I, Gottesman MM
Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transporters.
Cancer Res. 1995 Mar 1;55(5):1086-91., 1995-03-01 [PubMed]
Sentences
No. Mutations Sentence Comment
29 ABCB1 p.Gly185Val
X
ABCB1 p.Gly185Val 7866993:29:37
status: NEW
view ABCB1 p.Gly185Val details
 The well-characterized mutation of a glycine to valine at residue 185 in a colchicine-selected human KB cell line changes the pattern of resistance by improving the ability of the mutant to pump colchicine and etoposide while decreasing its ability to pump vinblastine and actinomycin D (14, 31). Login to comment 131 ABCB1 p.Gly185Val
X
ABCB1 p.Gly185Val 7866993:131:20
status: NEW
view ABCB1 p.Gly185Val details
 The substitution of valine for glycine at position 185 appears to increase interactions of cyclosporin A and quinidine with the trans porter so as to more effectively block transport of colchicine, dauno rubicin, and taxol. Login to comment