PMID: 7706385

Sardini A, Mintenig GM, Valverde MA, Sepulveda FV, Gill DR, Hyde SC, Higgins CF, McNaughton PA
Drug efflux mediated by the human multidrug resistance P-glycoprotein is inhibited by cell swelling.
J Cell Sci. 1994 Dec;107 ( Pt 12):3281-90., [PubMed]
Sentences
No. Mutations Sentence Comment
36 ABCB1 p.Lys1076Met
X
ABCB1 p.Lys1076Met 7706385:36:193
status: NEW
view ABCB1 p.Lys1076Met details
ABCB1 p.Lys433Met
X
ABCB1 p.Lys433Met 7706385:36:183
status: NEW
view ABCB1 p.Lys433Met details
 Plasmids, mutagenesis and transient expression system Plasmids pMDR7, expressing the human MDR1 gene, and pMDR712, expressing the human MDR1 gene mutated in both ATP binding domains (K433M and K1076M), were constructed as previously described (Valverde et al., 1992; Gill et al., 1992). Login to comment