PMID: 7540563

Manavalan P, Dearborn DG, McPherson JM, Smith AE
Sequence homologies between nucleotide binding regions of CFTR and G-proteins suggest structural and functional similarities.
FEBS Lett. 1995 Jun 12;366(2-3):87-91., [PubMed]
Sentences
No. Mutations Sentence Comment
170 ABCC7 p.Asp572Asn
X
ABCC7 p.Asp572Asn 7540563:170:27
status: NEW
view ABCC7 p.Asp572Asn details
ABCC7 p.Lys464Gln
X
ABCC7 p.Lys464Gln 7540563:170:20
status: NEW
view ABCC7 p.Lys464Gln details
 The NBDI mutations (K464Q, D572N) showed a decrease in sensitivity to IBMX activation while the equivalent NBD2 mutations (KI250Q, DI370N) produced an increase in IBMX sensitivity, These results together with our sequence analysis data suggest that the nature of nuclcotide binding and the subsequent conforma- tior~:,lchanges may differ for the two domains. Login to comment 171 ABCC7 p.Asp572Asn
X
ABCC7 p.Asp572Asn 7540563:171:27
status: NEW
view ABCC7 p.Asp572Asn details
ABCC7 p.Lys464Gln
X
ABCC7 p.Lys464Gln 7540563:171:20
status: NEW
view ABCC7 p.Lys464Gln details
 The NBDI mutations (K464Q, D572N) showed a decrease in sensitivity to IBMX activation while the equivalent NBD2 mutations (KI250Q, DI370N) produced an increase in IBMX sensitivity, These results together with our sequence analysis data suggest that the nature of nuclcotide binding and the subsequent conforma- tior~:,lchanges may differ for the two domains. Login to comment