PMID: 7532021

Carson MR, Travis SM, Winter MC, Sheppard DN, Welsh MJ
Phosphate stimulates CFTR Cl- channels.
Biophys J. 1994 Nov;67(5):1867-75., [PubMed]
Sentences
No. Mutations Sentence Comment
186 ABCC7 p.Ser660Ala
X
ABCC7 p.Ser660Ala 7532021:186:135
status: NEW
view ABCC7 p.Ser660Ala details
 To determine whether the R domain is necessary for Pi stimulation of CFITR Cl-current, we examined two mutant CFTRs; CFTRAR and CFTRAR-S660A. Login to comment 187 ABCC7 p.Ser660Ala
X
ABCC7 p.Ser660Ala 7532021:187:136
status: NEW
view ABCC7 p.Ser660Ala details
 To determine whether the R domain is necessary for Pi stimulation of CFITR Cl- current, we examined two mutant CFTRs; CFTRAR and CFTRAR-S660A. Login to comment 188 ABCC7 p.Ser660Ala
X
ABCC7 p.Ser660Ala 7532021:188:10
status: NEW
view ABCC7 p.Ser660Ala details
 In CFTRAR-S660A, amino acids 708-835 are deleted and serine 660 (a PKA phosphorylation site) is mutated to alanine. Login to comment 189 ABCC7 p.Ser660Ala
X
ABCC7 p.Ser660Ala 7532021:189:10
status: NEW
view ABCC7 p.Ser660Ala details
 In CFTRAR-S660A, amino acids 708-835 are deleted and serine 660 (a PKA phosphorylation site) is mutated to alanine. Login to comment 190 ABCC7 p.Ser660Ala
X
ABCC7 p.Ser660Ala 7532021:190:122
status: NEW
view ABCC7 p.Ser660Ala details
 Stimulation was not dependent on the presence of serine 660, because we observed similar stimulation in the mutant CFTRAR-S660A (n = 6, not shown). Login to comment 191 ABCC7 p.Ser660Ala
X
ABCC7 p.Ser660Ala 7532021:191:122
status: NEW
view ABCC7 p.Ser660Ala details
 Stimulation was not dependent on the presence of serine 660, because we observed similar stimulation in the mutant CFTRAR-S660A (n = 6, not shown). Login to comment