PMID: 7511206

van Es HH, Karcz S, Chu F, Cowman AF, Vidal S, Gros P, Schurr E
Expression of the plasmodial pfmdr1 gene in mammalian cells is associated with increased susceptibility to chloroquine.
Mol Cell Biol. 1994 Apr;14(4):2419-28., [PubMed]
Sentences
No. Mutations Sentence Comment
289 ABCB4 p.Asn1042Asp
X
ABCB4 p.Asn1042Asp 7511206:289:49
status: NEW
view ABCB4 p.Asn1042Asp details
 We expressed one of these pfmdrl alleles, S1034C/N1042D, in CHO cells and did not see the change in CQ sensitivity and accumulation as observed with wild-type Pghl, the form of Pghl commonly expressed in CQS parasites. Login to comment 303 ABCB4 p.Asn1042Asp
X
ABCB4 p.Asn1042Asp 7511206:303:107
status: NEW
view ABCB4 p.Asn1042Asp details
 In the absence of other plasmodial proteins, we have shown that at least one CQR-associated allele (S1034C/N1042D) abolishes the Pghl-mediated increase in CQ sensitivity and uptake into CHO cells. Login to comment