PMID: 26592666

Cai M, Bompada P, Atac D, Laakso M, Groop L, De Marinis Y
Epigenetic regulation of glucose-stimulated osteopontin (OPN) expression in diabetic kidney.
Biochem Biophys Res Commun. 2016 Jan 1;469(1):108-13. doi: 10.1016/j.bbrc.2015.11.079. Epub 2015 Nov 22., [PubMed]
Sentences
No. Mutations Sentence Comment
70 ABCC8 p.Glu1506Lys
X
ABCC8 p.Glu1506Lys 26592666:70:147
status: NEW
view ABCC8 p.Glu1506Lys details
 Blood glucose and OPN gene expression in the kidney increased in parallel in the diabetic mouse model Sur1-E1506K&#fe;/&#fe; Human carriers of the E1506K mutation in the SUR1 (ABCC8) gene exhibit neonatal hyperinsulinism and hypoglycemia, but develop later in life diabetes due to reduced functional b-cell mass Fig. 2. Login to comment 73 ABCC8 p.Glu1506Lys
X
ABCC8 p.Glu1506Lys 26592666:73:141
status: NEW
view ABCC8 p.Glu1506Lys details
 Spp1 expression levels are significantly correlated with H3K9ac (E), H3K4me1 (F), H3K4me3 (G) and H3K27me3 (H) levels in the kidneys of Sur1-E1506K mice of 8, 16, 24 and 32 weeks of age (n &#bc; 44 mice). Login to comment 78 ABCC8 p.Glu1506Lys
X
ABCC8 p.Glu1506Lys 26592666:78:130
status: NEW
view ABCC8 p.Glu1506Lys details
 The Sur1-E1506K&#fe;/&#fe; mouse model was developed to recapitulate this human mutation by a knock-in mutation at the equivalent E1506K of the SUR1 subunit [20] in C57Bl mouse strain. Login to comment