PMID: 26115671

Molina SA, Stauffer B, Moriarty HK, Kim AH, McCarty NA, Koval M
Junctional abnormalities in human airway epithelial cells expressing F508del CFTR.
Am J Physiol Lung Cell Mol Physiol. 2015 Sep 1;309(5):L475-87. doi: 10.1152/ajplung.00060.2015. Epub 2015 Jun 26., [PubMed]
Sentences
No. Mutations Sentence Comment
317 ABCC7 p.Trp1282*
X
ABCC7 p.Trp1282* 26115671:317:305
status: NEW
view ABCC7 p.Trp1282* details
 To confirm the observation that Cx43 mistrafficking in CuFi-5 cells was due to F508del CFTR expression, we examined Cx43 expression, localization, and gap junction-mediated dye transfer in IB3-1 cells, a different airway cell line that expresses one copy of F508del CFTR and one copy of a truncated CFTR, W1282X (Fig. 7). Login to comment 366 ABCC7 p.Trp1282*
X
ABCC7 p.Trp1282* 26115671:366:81
status: NEW
view ABCC7 p.Trp1282* details
 Cx43 gap junction function is rescued by 4-PBA treatment of heterozygous F508del/W1282X CFTR-expressing IB3-1 cells. Login to comment