PMID: 25918357

Puljung MC
New structural insights into the gating movements of CFTR.
J Gen Physiol. 2015 May;145(5):365-9. doi: 10.1085/jgp.201511399., [PubMed]
Sentences
No. Mutations Sentence Comment
79 ABCC7 p.Lys1250Arg
X
ABCC7 p.Lys1250Arg 25918357:79:164
status: NEW
view ABCC7 p.Lys1250Arg details
 To provide further evidence that the modification rates were limited by separation of the NBD dimer upon channel closure, the authors took advantage of a mutation (K1250R) in the Walker A motif of CS2. Login to comment 82 ABCC7 p.Lys1250Arg
X
ABCC7 p.Lys1250Arg 25918357:82:7
status: NEW
view ABCC7 p.Lys1250Arg details
 In the K1250R background, modification of cysteines in the signature sequences of both composite sites occurred at a much slower rate. Login to comment