PMID: 24911077

Nahar R, Saxena R, Deb R, Parakh R, Shad S, Sethi PK, Takkar P, Verma IC
CYP2C9, VKORC1, CYP4F2, ABCB1 and F5 variants: influence on quality of long-term anticoagulation.
Pharmacol Rep. 2014 Apr;66(2):243-9. doi: 10.1016/j.pharep.2013.09.006. Epub 2014 Mar 3., [PubMed]
Sentences
No. Mutations Sentence Comment
34 ABCB1 p.Ser893Ala
X
ABCB1 p.Ser893Ala 24911077:34:769
status: NEW
view ABCB1 p.Ser893Ala details
 Nine variants in CYP2C9 (*2/rs1799853/430C>T/p.Cys144Arg in exon 3; *3/rs1057910/c.1075A>C/p.Ileu359Leu in exon 7; rs9332120, c.331+73T>C in intron 2; rs9332230, c.1291+53A>T in intron 8; rs2298037, c.1291+147C>T in intron 8; *14/rs72558189, c.374G>A/p.Arg125His in exon 2; rs9332172, c.820-73A>G in intron 5; rs1057911, c.1425A>T/p.Gly475Gly in exon 9; and c.610A>C, *57/p.Asn204His in exon 4), four variants in VKORC1 (1639G>A/g.3588G>A/rs9923231 in upstream promoter region; rs9934438, c.1173C>T in intron 2; rs7294, c.516G>A/ 3730G>A in 30 UTR and rs55894764/c.36G>A/p.Arg12Arg in exon 1), CYP4F2 rs2108622 (c.1297G>A/p.Val433Met in exon 11), three common polymorphisms in the MDR1/ABCB1 gene (rs1128503/ c.1236T>C/p.Gly412Gly in exon 12; rs2032582/c.2677T>G/A/ p.Ser893Ala/Thr in exon 21 and rs1045642/c.3435C>T/ p.Ile1145Ile in exon 26), APOE isoforms (e2, e3, e4 distinguished by two non synonymous polymorphisms; rs7212 and rs229358), factor V Leiden variant in F5 (rs6025/1691G>A/p.Arg506Gln) and prothrombin variant in F2 (rs1799963/20210G>A in 30 UTR) were genotyped. Login to comment