PMID: 24875445

Lorendeau D, Dury L, Genoux-Bastide E, Lecerf-Schmidt F, Simoes-Pires C, Carrupt PA, Terreux R, Magnard S, Di Pietro A, Boumendjel A, Baubichon-Cortay H
Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux.
Biochem Pharmacol. 2014 Aug 1;90(3):235-45. doi: 10.1016/j.bcp.2014.05.017. Epub 2014 May 27., [PubMed]
Sentences
No. Mutations Sentence Comment
84 ABCC1 p.Lys1333Leu
X
ABCC1 p.Lys1333Leu 24875445:84:80
status: NEW
view ABCC1 p.Lys1333Leu details
 BHK-21 (Baby Hamster Kidney-21) cells stably transfected with wild-type mrp1 or K1333L mrp1 mutant have been previously described [25,26]. Login to comment 175 ABCC1 p.Lys1333Leu
X
ABCC1 p.Lys1333Leu 24875445:175:212
status: NEW
view ABCC1 p.Lys1333Leu details
 Flavonoids (flavonoid 8, 11 and 22 for the most active ones), like verapamil, are only effective on BHK-21 cells overexpressing wild-type MRP1 and not on those overexpressing MRP1 mutated in its hydrolytic site (K1333L) (Fig. 5) suggesting that the functional transporter is required to induce selective cell death. Login to comment