ABCMdb

PMID: 24756092

Kim HN, Kim NY, Yu L, Kim YK, Lee IK, Yang DH, Lee JJ, Shin MH, Park KS, Choi JS, Kim HJ
Polymorphisms in DNA repair genes and MDR1 and the risk for non-Hodgkin lymphoma.
Int J Mol Sci. 2014 Apr 21;15(4):6703-16. doi: 10.3390/ijms15046703., [PubMed]

Sentences

No. Mutations Sentence Comment

26 ABCB1 p.Ser893Thr Genotype Primers and probe Method Reference DNA repair pathway ERCC1 rs3212961 A/C, IVS5 +33 F: TTGTCCAGGTGGATGTGGTA R: CCTCGCTGAGGTTTTAGCTG HRM ERCC2/XPD rs13181 G/T, Lys751Gln F: TCAAACATCCTGTCCCTACT R: CTGCGATTAAAGGCTGTGGA RFLP: PstI XPC rs2228001 A/C, Lys939Gln F: CCTCAAAACCGAGAAGATGAAG R: CAGGTGTGGGGCCTGTAGT HRM XRCC3 rs861539 C/T, Thr241Met F: CCATTCCGCTGTGAATTTG R: GAAGGCACTGCTCAGCTCAC HRM RAD51 rs1801321 G/T, 172 in 5'-UTR F: GTAGAGAAGTGGAGCGTAAGCC R: Biotin-CTGCGCCTCACACACTCA S: GGGGGCCGTGCGGGT PSQ XRCC4 rs1056503 G/T, Ser307Ser F: AGGCCTGATTCTTCACTACCTG R: GGCTGCTGTTTCTCAGAGTTTC HRM XRCC1 rs1799782 C/T, Arg194Trp F: ATAATACTGACCTTGCGGGACC R: Biotin-ACCCACGAGTCTAGGTCTCAA S: CTGAGGCCGGGGGCT PSQ XRCC1 rs25487 G/A, Arg399Gln F: TCTCCCTTGGTCTCCAACCT R: AGTAGTCTGCTGGCTCTGG RFLP: HpaII [31] OGG1 rs1052133 C/G, Ser326Cys F: CCCTCCTACAGGTGCTGTTC R: TGGGGAATTTCTTTGTCCAG HRM MGMT rs12917 C/T, Leu115Phe F: Biotin-CCCCTGTTCTCACTTTTGCA R: ACTGTGATGTCAGCGATCGTTAAT S: AAACGGGATGGTGAA PSQ BRCA1 rs799917 C/T, Pro871Leu F: CCACAGTCGGGAAACAAGCATAGA R: CTTCTGCATTTCCTGGATTTGAAACC RFLP: HpaII [32] WRN rs1800392 G/T, Leu787Leu F: TGGGAATTTGAAGGTCCAAC R: GCATGGTATGTTCCACAGGA HRM Multidrug resistance ABCB1 rs1128503 1236, T/C, Gly412Gly F: TCTTTGTCAC TTTATCCAGC R: TCTCACCATC CCCTCTGT RFLP: EcoO191I [33] ABCB1 rs2032582 2677, G/T/A, Ser893Thr/Ala F: TGCAGGCTATAGGTTCCAGG R: TTTAGTTTGACTCACCTTCCCG RFLP: Ban1, Rsa1 [34] ABCB1 rs1045682 3435, C/T, Ile1145 Ile F: GAGCCCATCCTGTTTGACTG R: AGAGAGGCTGCCACATGCT RFLP: Mbo1 [34] PSQ: Pyrosequencing; HRM: High-resolution melter; RFLP: Restriction fragment length polymorphism. Login to comment 41 ABCB1 p.Ser893Thr SNP Genotype/ Haplotype Control n (%) NHL DLBCL T-cell lymphoma n (%) OR * (95% CI) p n (%) OR * (95% CI) p n (%) OR * (95% CI) p ABCB1 1236 TT 580 (34) 234 (34) 1 139 (37) 1 44 (32) 1 Gly412Gly TC 825 (49) 367 (53) 1.11 (0.91-1.36) 0.29 193 (51) 1.00 (0.78-1.28) 0.98 74 (53) 1.18 (0.80-1.74) 0.41 rs1128503 CC 295 (17) 87 (13) 0.74 (0.56-0.98) 0.04 44 (12) 0.64 (0.44-0.93) 0.02 21 (15) 0.93 (0.54-1.60) 0.80 TT/CC 1120 (66) 454 (66) 1.01 (0.84-1.22) 0.89 237 (63) 0.90 (0.71-1.14) 0.39 95 (68) 1.11 (0.77-1.62) 0.57 ABCB1 2677 GG 323 (19) 131 (19) 1 64 (17) 1 29 (21) 1 Ser893 Thr/Ala GW ߤ 886 (52) 340 (50) 0.96 (0.75-1.22) 0.74 189 (51) 1.10 (0.81-1.51) 0.54 69 (50) 0.86 (0.55-1.35) 0.51 rs2032582 WW 488 (29) 210 (31) 1.07 (0.82-1.39) 0.61 115 (31) 1.21 (0.86-1.71) 0.27 41 (29) 0.92 (0.56-1.51) 0.74 GW/WW 1374 (81) 550 (81) 1.00 (0.80-1.26) 0.99 304 (82) 1.14 (0.85-1.54) 0.39 110 (79) 0.88 (0.57-1.35) 0.56 ABCB1 3435 CC 708 (42) 234 (34) 1 128 (34) 1 46 (33) 1 Ile1145 Ile CT 800 (47) 377 (54) 1.50 (1.23-1.82) <0.0001 210 (56) 1.52 (1.19-1.94) 0.01 76 (54) 1.51 (1.04-2.22) 0.03 rs1045642 TT 192 (11) 83 (12) 1.43 (1.06-1.93) 0.02 40 (10) 1.25 (0.84-1.86) 0.27 18 (13) 1.54 (0.87-2.72) 0.14 CT/TT 992 (58) 460 (66) 1.48 (1.23-1.79) <0.0001 250 (66) 1.47 (1.16-1.86) 0.02 94 (67) 1.52 (1.05-2.19) 0.03 ABCB1 TTT 1037 (31) 444 (34) 1 242 (34) 1 88 (34) 1 HAP CGC 734 (22) 261 (20) 0.83 (0.69-0.995) 0.04 132 (19) 0.77 (0.61-0.98) 0.03 53 (20) 0.85 (0.60-1.21) 0.38 TGC 713 (21) 270 (21) 0.88 (0.73-1.05) 0.15 152 (22) 0.90 (0.71-1.13) 0.35 54 (21) 0.91 (0.64-1.29) 0.59 CAC 583 (18) 211 (16) 0.84 (0.69-1.02) 0.08 117 (17) 0.87 (0.68-1.11) 0.25 44 (17) 0.89 (0.61-1.29) 0.53 TTC 186 (6) 70 (6) 0.90 (0.67-1.21) 0.48 45 (6) 1.07 (0.75-1.53) 0.72 11 (4) 0.73 (0.38-1.39) 0.34 CGT 62 (2) 41 (3) 1.67 (1.10-2.54) 0.02 16 (2) 1.22 (0.68-2.18) 0.51 12 (4) 2.48 (1.28-4.79) 0.007 * ORs and 95% CIs were estimated using multiple logistic regression and adjusted for sex and age; ߤ W indicated all alleles except G allele. Login to comment