PMID: 24566881

Venerando A, Cesaro L, Marin O, Donella-Deana A, Pinna LA
A "SYDE" effect of hierarchical phosphorylation: possible relevance to the cystic fibrosis basic defect.
Cell Mol Life Sci. 2014 Jun;71(12):2193-6. doi: 10.1007/s00018-014-1581-8. Epub 2014 Feb 25., [PubMed]
Sentences
No. Mutations Sentence Comment
29 ABCC7 p.Tyr512Ala
X
ABCC7 p.Tyr512Ala 24566881:29:211
status: NEW
view ABCC7 p.Tyr512Ala details
 A scenario like this would also account for a number of phenomenological observations already available in the literature, notably the defective maturation and reduced cell surface exposition of the CFTR mutant Y512A [20], which, unlike the wild type, is expected to be susceptible to phosphorylation by CK2 at S511 (see Fig. 1) and the increased accumulation of F508delCFTR upon cell treatment with a very specific CK2 inhibitor [21]. Login to comment