PMID: 24145529

Obonaga R, Fernandez OL, Valderrama L, Rubiano LC, Castro Mdel M, Barrera MC, Gomez MA, Gore Saravia N
Treatment failure and miltefosine susceptibility in dermal leishmaniasis caused by Leishmania subgenus Viannia species.
Antimicrob Agents Chemother. 2014;58(1):144-52. doi: 10.1128/AAC.01023-13. Epub 2013 Oct 21., [PubMed]
Sentences
No. Mutations Sentence Comment
93 ABCC2 p.Thr420Asn
X
ABCC2 p.Thr420Asn 24145529:93:24
status: NEW
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 The presence of C1259A (T420N) and T2567C (L856P) polymorphisms in the LbMT gene, previously reported to be associated with experimentally derived miltefosine resistance (9), and G630A (W210*) analyzed in VL and post-kala-azar dermal leishmaniasis (PKDL) strains of L. donovani (19) were characterized by sequence analysis of PCR products. Login to comment 95 ABCC2 p.Thr420Asn
X
ABCC2 p.Thr420Asn 24145529:95:120
status: NEW
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ABCC2 p.Thr420Asn
X
ABCC2 p.Thr420Asn 24145529:95:162
status: NEW
view ABCC2 p.Thr420Asn details
 PCR was carried out using primer sets W210*-F (5=-AGGCGTTCATTG ACACATGC-3=) and W210*-R (5=-TACAGGAACTGGTTCAGCGAC- 3=); T420N-F (5=-TGGAGTACATGAACAACCGCT-3=) and T420N-R (5=- CTCTTCCTCCTTGCGCAGTC-3=), and L856P-F (5=-TCATTGGGCTGG AAGGTTCA-3=) and L856P-R (5=-GTGTTAGTCCCGAGAAGCCA-3=). Login to comment 150 ABCA2 p.Glu1348Ala
X
ABCA2 p.Glu1348Ala 24145529:150:49
status: NEW
view ABCA2 p.Glu1348Ala details
 Interestingly, the SNPs A615G, G691A, T699G, and G1348A were species specific, differentiating L. panamensis from L. braziliensis. Login to comment