PMID: 24122874

Prasad B, Evers R, Gupta A, Hop CE, Salphati L, Shukla S, Ambudkar SV, Unadkat JD
Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex.
Drug Metab Dispos. 2014 Jan;42(1):78-88. doi: 10.1124/dmd.113.053819. Epub 2013 Oct 11., [PubMed]
Sentences
No. Mutations Sentence Comment
179 ABCB1 p.Asn21Asp
X
ABCB1 p.Asn21Asp 24122874:179:823
status: NEW
view ABCB1 p.Asn21Asp details
 TABLE 4 Frequency of OATP1B1, OATP1B3, and P-gp SNPs detected in the University of Washington (UW) liver bank Marker ID Variant Change for Variant Frequency in UW liver Bank Homozygous Variant Heterozygous Variant Wild-Type OATP1B1 rs4149015 211187G.A Promoter 0 9 53 rs2306283 388A.G N130D 10 30 22 rs11045819 463C.A P155T 4 9 49 rs4149056 521T.C V174A 1 21 40 rs4149057 571T.C L191L 16 34 12 rs2291075 597C.T F199F 10 33 19 OATP1B3 rs4149117 334G.T A112S 0 45 17 rs7311358 699A.G I233M 0 45 17 rs2053098 1557G.A A519A 0 45 17 rs3764006 1833A.G G611G 0 42 20 P-gp rs2214102 21G.A 59UTR 0 6 56 rs2235015 287-25G.T Intron 0 19 43 rs10276036 IVS9-44A.G Intron 19 31 12 rs1128503 1236C.T G412G 18 33 11 rs2032588 1350+44C.T Intron 0 7 55 rs2235033 1554+24C.T Intron 22 32 8 rs2235013 1725+38A.G Intron 21 33 8 rs9282564 61A.G N21D 7 11 45 rs2235040 2481+24G.A Intron 0 12 50 rs2032582 2677G.T, 2677G.A A893S, A893T 17 32 13 rs3213619 2129T.C 59UTR 0 4 58 rs1045642 3435C.T I1145I 22 30 10 rs17064 *89A.T 39UTR 0 7 55 rs3842 *193A.G 39UTR 0 18 44 OATP, organic anion-transporting polypeptide; P-gp, P-glycoprotein; SNP, single nucleotide polymorphisms; UW, University of Washington. Login to comment