ABCMdb

PMID: 23807484

Guo H, Li Q, Chou DW, Uitto J
Atorvastatin counteracts aberrant soft tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6(-)/(-)).
J Mol Med (Berl). 2013 Oct;91(10):1177-84. doi: 10.1007/s00109-013-1066-5. Epub 2013 Jun 27., [PubMed]

Sentences

No. Mutations Sentence Comment

1 ABCC6 p.Arg1141* Previous studies have suggested that carriers of the ABCC6 mutations, particularly of p.R1141X, are at increased risk for coronary artery disease. Login to comment 23 ABCC6 p.Arg1141* However, it has been suggested that heterozygous carrier status of loss-of-function mutations in the ABCC6 gene, particularly that of p.R1141X, the most common mutation in the Caucasian populations, is associated with a strong increase in the prevalence of coronary artery disease [13, 14]. Login to comment