ABCMdb

PMID: 23784545

Cai Z, Li H, Chen JH, Sheppard DN
Acute inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel by thyroid hormones involves multiple mechanisms.
Am J Physiol Cell Physiol. 2013 Oct 15;305(8):C817-28. doi: 10.1152/ajpcell.00052.2013. Epub 2013 Jun 19., [PubMed]

Sentences

No. Mutations Sentence Comment

232 ABCC7 p.Gly551Asp By contrast, D&#e9;rand et al. (16) demonstrated that allosteric inhibition of CFTR by genistein is abolished by the CF mutant G551D-CFTR, which affects a key residue in ATP-binding site 2, the site of rapid ATP hydrolysis in the ATP-driven NBD dimerization model of CFTR channel gating (60, 61). Login to comment 251 ABCC7 p.Arg347Glu ABCC7 p.Arg352Glu ABCC7 p.Arg334Cys The occurrence of subconductance states is more frequent in some site-directed mutations in the MSDs [e.g., R334C-CFTR (70), R347E-CFTR (11), and R352E-CFTR (13)], while wild-type murine CFTR resides for prolonged periods in a minuscule subconductance state and only transitions infrequently to the full open-state (37). Login to comment 257 ABCC7 p.Arg352Cys Recognizing that sojourns to subconductance states in Cysless-R352C-CFTR mimic the behavior of wild-type CFTR blocked by MOPS, Jih et al. (33) developed the energetic coupling model of CFTR channel gating (for review, see Ref. 32). Login to comment