ABCMdb

PMID: 23717663

Subenthiran S, Abdullah NR, Joseph JP, Muniandy PK, Mok BT, Kee CC, Ismail Z, Mohamed Z
Linkage disequilibrium between polymorphisms of ABCB1 and ABCC2 to predict the treatment outcome of Malaysians with complex partial seizures on treatment with carbamazepine mono-therapy at the Kuala Lumpur Hospital.
PLoS One. 2013 May 23;8(5):e64827. doi: 10.1371/journal.pone.0064827. Print 2013., [PubMed]

Sentences

No. Mutations Sentence Comment

5 ABCB1 p.Gly1249Ala Our study is aimed at determining the correlation between patients` response to CBZ mono-therapy to Single Nucleotide Polymorphisms G2677T and C3435T of the ABCB1 gene as well as G1249A and 224C.T of the ABCC2 gene. Login to comment 11 ABCB1 p.Gly1249Ala Results: Resistance to treatment with CBZ mono-therapy was significantly associated with the 2677TT and the 3435TT genotypes while it was not significantly associated with the G1249A and 224C.T polymorphisms. Login to comment 136 ABCB1 p.Gly1249Ala Genotype frequency (%) *Permuted *Permuted SNP / Genotype Responder Non-responder x2 p ABCB1/ C3435T C/C 35(0.22) 51(0.34) 12.06 0.007 T/T 68(0.42) 36(0.24) C/T 59(0.36) 65(0.43) ABCB1/ G2677T G/G 59(0.36) 144(0.75) 61.70 ,0.001 T/T 57(0.35) 25(0.16) G/T 46(0.28) 13(0.09) ABCC2/ G1249A G/G 120(0.74) 124(0.82) 2.23 0.511 A/A 0(0.00) 1(0.01) G/A 42(0.26) 27(0.18) ABCC2/ 224C.T C/C 110(0.68) 102(0.67) 0.14 0.986 T/T 4(0.03) 6(0.04) C/T 48(0.30) 44(0.29) *1000 permutation applied. Login to comment 140 ABCB1 p.Gly1249Ala We found no correlation between the G1249A of the ABCC2 gene and the outcome of treatment of patients with CPS on CBZ monotherapy. This is similar to the findings of the study conducted on German patients [30] and Chinese patients [31]. Login to comment