PMID: 23588565

Kim IW, Yun HY, Choi B, Han N, Kim MG, Park S, Oh JM
Population pharmacokinetics analysis of cyclophosphamide with genetic effects in patients undergoing hematopoietic stem cell transplantation.
Eur J Clin Pharmacol. 2013 Aug;69(8):1543-51. doi: 10.1007/s00228-013-1507-7. Epub 2013 Apr 16., [PubMed]
Sentences
No. Mutations Sentence Comment
143 ABCB1 p.Gly1249Ala
X
ABCB1 p.Gly1249Ala 23588565:143:49
status: NEW
view ABCB1 p.Gly1249Ala details
 We found that CLUI was associated with the ABCC2 G1249A genotype. ABCC2 has been reported to mediate biliary transport of 4-glutathionylcyclophosphamide [42] but has not been reported to transport CY itself. Login to comment 145 ABCB1 p.Gly1249Ala
X
ABCB1 p.Gly1249Ala 23588565:145:78
status: NEW
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 In another study, patients carrying the heterozygous variant alleles of ABCC2 G1249A exhibited higher exposure of acyl mycophenolate phenolic glucuronide than those with the wild-type genotype [43]. Login to comment 177 ABCB1 p.Gly1249Ala
X
ABCB1 p.Gly1249Ala 23588565:177:52
status: NEW
view ABCB1 p.Gly1249Ala details
 We demonstrated that carriers of at least one ABCC2 G1249A allele had a decreased CLUI. Login to comment