PMID: 23537407

Clarke LA, Sousa L, Barreto C, Amaral MD
Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies.
Respir Res. 2013 Mar 28;14:38. doi: 10.1186/1465-9921-14-38., [PubMed]
Sentences
No. Mutations Sentence Comment
12 ABCC7 p.Trp1282*
X
ABCC7 p.Trp1282* 23537407:12:219
status: NEW
view ABCC7 p.Trp1282* details
 Several CF transcriptomics studies have employed microarrays to measure differences in global gene expression caused by the F508del mutation in isogenic bronchial cells [16] (in this case the CFTR genotype was F508del/ W1282X), primary cultures of tracheal and bronchial cells [17], native nasal epithelial and bronchial cells [18,19] and * Correspondence: laclarke@fc.ul.pt 1 BioFIG - Centre for Biodiversity, Functional and Integrative Genomics; FCUL -Faculty of Sciences, University of Lisboa, Lisboa 1749-016, Portugal Full list of author information is available at the end of the article (c) 2013 Clarke et al. Login to comment 108 ABCC7 p.Trp1282*
X
ABCC7 p.Trp1282* 23537407:108:132
status: NEW
view ABCC7 p.Trp1282* details
 vs. 5 controls Affymetrix Custom HsAirwaya520108F Virella-Lowell et al., 2004 [16]1 Isogenic bronchial cells (IB3-1 and S9) F508del/W1282X vs. WT-CFTR corrected: 3 technical replicates each Affymetrix U95Av2 Zabner et al., 2005 [17]1 Primary tracheal and bronchial cell cultures 10 CF (F508del homoz.) Login to comment