PMID: 23357434

Gong LL, Fang LH, Wang HY, Peng JH, Si K, Zhu J, Han FF, Wang YH, Du GH, Pei LX, Liu LH
Genetic risk factors for glucocorticoid-induced osteonecrosis: a meta-analysis.
Steroids. 2013 Apr;78(4):401-8. doi: 10.1016/j.steroids.2013.01.004. Epub 2013 Jan 25., [PubMed]
Sentences
No. Mutations Sentence Comment
82 ABCB1 p.Ala313Gly
X
ABCB1 p.Ala313Gly 23357434:82:1545
status: NEW
view ABCB1 p.Ala313Gly details
 Gene rs No./genotype Number of cases/ controls Case Control Number of studies Refs. 11 12 22 11 12 22 1 PAI-1 -675 4G/5G 108/917 50 46 12 225 455 237 4 [8,10,24,36] rs6092 89/281 59 29 1 240 41 0 2 [31,35] 2 MTHFR C677T 103/537 61 31 11 324 168 45 5 [10,23-25,31] A1298C 25/39 8 15 2 16 21 2 1 [23] 3 Factor V Leiden N/A 26/39 24 2 0 35 4 0 2 [10,25] 4 Prothrombin G20210A 26/39 26 0 0 35 4 0 2 [10,25] 5 CBP rs3751845 113/246 68 23 22 105 36 105 2 [14,29] 6 ABCB1 C3435T 148/462 83 55 10 210 171 81 6 [14,21,23,30,31,34] G2677T/A 136/268 48 45 13 82 124 62 4 [21,23,30,34] 7 TYMS Enhancer repeat 25/39 5 13 7 16 19 4 2 [23,31] 8 VDR rs2228570 T/C 68/299 42 26 187 112 2 [23,31] Intron 8 G/A 25/39 12 8 5 14 18 7 1 [23] 9 ApoB C7623T 66/244 54 12 230 14 2 [12,14] G12619A 34/123 33 1 112 11 1 [12] 10 ApoA1 -75G/A 33/120 22 11 86 34 1 [12] C83T 33/120 29 4 106 14 1 [12] 11 LRP5 rs2306862 T/C 40/212 18 22 113 99 1 [31] 12 NR3C1 A1220G 25/39 25 0 0 38 1 0 1 [23] rs6196 T/C 34/123 31 3 0 115 8 0 1 [29] rs2282800 34/123 1 2 31 8 22 93 1 [29] 13 SREBP-2 T8408C 56/270 16 31 9 77 138 55 1 [32] G342T 54/422 32 20 2 241 149 32 1 [32] G414A 56/271 22 30 4 132 120 19 1 [32] G1667A 56/266 22 26 8 116 121 29 1 [32] 14 CYP3A4 /1B A/G 25/39 23 2 0 34 2 3 1 [23] rs3735451 34/123 24 9 1 77 46 0 1 [29] 15 CYP2D6 EM/IM/PM 26/54 21 5 0 45 9 0 1 [22] 16 CYP2C19 EM/PM 54/26 46 0 8 23 0 3 1 [22] 17 CYP3A5 /3 G/A 25/39 20 5 0 29 7 3 1 [23] 18 UGT1A1 /28 25/39 11 9 5 14 20 5 1 [23] 19 GSTM1 257 bp deletion (non-null/null) 25/39 14 11 26 13 1 [23] 20 GSTP1 A313G 25/39 5 16 4 13 19 7 1 [23] 21 GSTT1 Deletion (non-null/null) 24/39 18 6 32 7 1 [23] 22 TMPT /1//3 25/39 22 3 0 37 2 0 1 [23] 23 RFC G80A 25/39 10 11 4 12 18 9 1 [23] 24 NOS 27 bp repeat polymorphism in intron 4 29/103 0 3 26 0 5 98 1 [26] D298E 29/103 0 4 25 0 20 83 1 [26] 25 HIF C2755A 59/237 20 29 10 78 117 42 1 [27] T41224C 56/236 28 25 3 135 84 17 1 [27] C45319T 59/236 52 7 0 219 16 1 1 [27] C51610T 56/234 35 18 3 156 68 10 1 [27] 26 PPAR A796G 55/330 36 16 3 223 95 12 1 [28] C34G 54/328 51 3 0 296 32 0 1 [28] C82466T 55/333 39 15 1 242 85 6 1 [28] 27 NcoA2 rs2272670 C/T 34/123 22 11 1 62 50 11 1 [29] 28 BGLAP rs1800247 T/C 36/203 32 4 183 20 1 [31] 29 ESR1 rs2234693 C/T 32/190 13 19 95 95 1 [31] 30 PTH rs6254 A/G 44/229 19 25 115 114 1 [31] 31 PTHR rs1138518 C/T 35/213 16 19 117 96 1 [31] 32 ACP5 rs2229531 A/G 43/222 5 38 31 191 1 [31] rs2305799 T/C 43/235 8 35 54 181 1 [31] 33 TNFa T-1031C 15/35 6 8 1 28 7 0 1 [33] C-863A 16/37 9 7 0 33 4 0 1 [33] C-857T 16/37 12 4 0 26 11 0 1 [33] A-572C 16/37 16 0 0 36 1 0 1 [33] G-308A 16/37 14 2 0 32 4 1 1 [33] G-238A 16/37 13 3 0 33 4 0 1 [33] 34 VEGF A-2575C 74/160 5 24 45 9 68 83 1 [37] A-1154G 74/160 0 11 63 6 46 108 1 [37] C-634G 136/380 35 66 35 65 198 117 2 [37,39] C405G 74/160 19 33 22 25 84 51 1 [37] 35 Hapatic lipase rs59644784 A/G 143/96 20 69 54 16 43 37 1 [38] rs1800588 C/T 143/96 58 68 17 41 42 13 1 [38] 11 Indicate wild type genotype, 12 indicate heterozygous genotype, 22 indicate mutant genotype. Login to comment