PMID: 23261525

Natarajan K, Bhullar J, Shukla S, Burcu M, Chen ZS, Ambudkar SV, Baer MR
The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms.
Biochem Pharmacol. 2013 Feb 15;85(4):514-24. doi: 10.1016/j.bcp.2012.12.006. Epub 2012 Dec 19., [PubMed]
Sentences
No. Mutations Sentence Comment
22 ABCG2 p.Thr362Ala
X
ABCG2 p.Thr362Ala 23261525:22:124
status: NEW
view ABCG2 p.Thr362Ala details
 Additionally, Pim-1 phosphorylates ABCG2 at threonine 362, knocking down Pim-1 abolishes ABCG2 multimer formation and ABCG2 T362A mutation decreases ABCG2 expression on the cell surface [18]. Login to comment