PMID: 23115734

Kim SH, Jee YK, Lee JH, Lee BH, Kim YS, Park JS, Kim SH
ABCC2 Haplotype is Associated With Antituberculosis Drug-Induced Maculopapular Eruption.
Allergy Asthma Immunol Res. 2012 Nov;4(6):362-6. doi: 10.4168/aair.2012.4.6.362. Epub 2012 May 24., [PubMed]
Sentences
No. Mutations Sentence Comment
35 ABCC2 p.Val417Ile
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ABCC2 p.Val417Ile 23115734:35:368
status: NEW
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 Polymorphisms of ABCC2 in patients with ATD-induced MPE and controls Among seven SNPs in ABCC2, IVS3-49C>T and I1324I were significantly associated with ATD-induced MPE (P=0.029 for therecessivemodel,OR=3.15,95%CI:1.09-9.11andP=0.036for theallelemodel,OR=0.029,95%CI:1.12-9.53,respectively).The genotypefrequenciesoftheotherfiveABCC2SNPs(-1774del>G, -1549G>A, -24C>T, V417I, and S978S) did not differ between cases and control subjects (Table 2). Login to comment 51 ABCC2 p.Val417Ile
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ABCC2 p.Val417Ile 23115734:51:534
status: NEW
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 Genotype frequencies of SNPs in the ABCC2 gene in patients with ATD-induced MPE and ATD-tolerant controls SNP Genotype ATD-MPE (N=62) ATD-Control (N=159) Pvalue OR (95%CI) -1774del>G GG 23 (37.1%) 43 (27.4%) NS G/- 31 (50.0%) 94 (59.9%) -/- 8 (12.9%) 20 (12.7%) -1549G>A GG 30 (48.4%) 89 (57.1%) NS GA 24 (38.7%) 60 (38.5%) AA 8 (12.9%) 7 (4.5%) -24C>T CC 33 (53.2%) 92 (59.4%) NS CT 23 (37.1%) 57 (36.8%) TT 6 (9.7%) 6 (3.9%) IVS3-49C>T CC 30 (48.4%) 91 (57.2%) 0.029* 3.27 (1.12-9.53) CT 24 (38.7%) 61 (38.4%) TT 8 (12.9%) 7 (4.4%) V417I GG 52 (83.9%) 134 (84.3%) NS GA 9 (14.5%) 23 (14.5%) AA 1 (1.6%) 2 (1.3%) S978S GG 58 (93.6%) 147 (92.5%) NS GA 4 (6.4%) 12 (7.6%) AA 0 (0.0%) 0 (0.0%) I1324I CC 29 (46.8%) 91 (58.3%) 0.036ߤ 1.63 (1.03-2.60) CT 25 (40.3%) 56 (35.9%) TT 8 (12.9%) 9 (5.8%) *P value was calculated using the recessive model; ߤ P values were calculated using the allele model. Login to comment