PMID: 23103446

Kosztyu P, Dolezel P, Mlejnek P
Can P-glycoprotein mediate resistance to nilotinib in human leukaemia cells?
Pharmacol Res. 2013 Jan;67(1):79-83. doi: 10.1016/j.phrs.2012.10.012. Epub 2012 Oct 26., [PubMed]
Sentences
No. Mutations Sentence Comment
14 ABCB1 p.Glu255Val
X
ABCB1 p.Glu255Val 23103446:14:158
status: NEW
view ABCB1 p.Glu255Val details
 Preclinical studies indicated that nilotinib is effective against several Bcr-Abl mutant forms that are found in patients with a diagnosis of Ph+ CML such as E255V, M351T, Q252H/R, Y253F, F317L, and E355G. Login to comment