PMID: 22971641

Kiyohara C, Miyake Y, Koyanagi M, Fujimoto T, Shirasawa S, Tanaka K, Fukushima W, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M
MDR1 C3435T polymorphism and interaction with environmental factors in risk of Parkinson's disease: a case-control study in Japan.
Drug Metab Pharmacokinet. 2012 Sep 11., [PubMed]
Sentences
No. Mutations Sentence Comment
68 ABCB1 p.Ser1141Thr
X
ABCB1 p.Ser1141Thr 22971641:68:72
status: NEW
view ABCB1 p.Ser1141Thr details
 All the subjects had the same genotype (TT) for MDR1 T3421A (rs2229107, Ser1141Thr) (data not shown). Login to comment 88 ABCB1 p.Ser1141Thr
X
ABCB1 p.Ser1141Thr 22971641:88:306
status: NEW
view ABCB1 p.Ser1141Thr details
 The frequency of the T allele in this study was somewhat lower than that of the HapMap SNP database but similar to that of other Japanese populations (41.3 %, 40.6 % and 39.0%).11, 26, 27) All Japanese as well as all Caucasians and all Han Chinese have the same genotype (TT) for the nonsynonymous T3421A (Ser1141Thr) polymorphism.28) In this study, subjects with the TT genotype of the C3435T polymorphism had a nonsignificantly increased risk of PD (OR = 1.39, 95% CI = 0.85 - 2.25) compared with the CC genotype. Login to comment