PMID: 22964850

Castellani S, Guerra L, Favia M, Di Gioia S, Casavola V, Conese M
NHERF1 and CFTR restore tight junction organisation and function in cystic fibrosis airway epithelial cells: role of ezrin and the RhoA/ROCK pathway.
Lab Invest. 2012 Nov;92(11):1527-40. doi: 10.1038/labinvest.2012.123. Epub 2012 Sep 10., [PubMed]
Sentences
No. Mutations Sentence Comment
34 ABCC7 p.Lys1468*
X
ABCC7 p.Lys1468* 22964850:34:66
status: NEW
view ABCC7 p.Lys1468* details
 Wild-type CFTR inserted in pcDNA3.1 was already described.16 CFTR K1468X lacking the 12 C-terminal amino acids,17 inserted into pTM1, was generously provided by Prof. MJ Welsh (University of Iowa, Iowa City, USA). Login to comment 103 ABCC7 p.Lys1468*
X
ABCC7 p.Lys1468* 22964850:103:29
status: NEW
view ABCC7 p.Lys1468* details
 Transfection of CFTR-NH2 and K1468X gave no effect on occludin, while in case of claudin 1 and JAM-1 it produced a less pronounced effect than transfection of wild-type CFTR and NHERF1 (Supplementary Figures 2-4). Login to comment