ABCMdb

PMID: 22869156

von Schonfels W, Buch S, Wolk M, Aselmann H, Egberts JH, Schreiber S, Krawczak M, Becker T, Hampe J, Schafmayer C
Recurrence of gallstones after cholecystectomy is associated with ABCG5/8 genotype.
J Gastroenterol. 2012 Aug 7., [PubMed]

Sentences

No. Mutations Sentence Comment

31 ABCG8 p.Asp19His We observed an association between risk variant ABCG8-D19H and post-surgery gallstone disease with a similar allelic odds ratio as for pre-cholecystectomy populations, thereby confirming the central pathophysiological role of this locus in the formation of gallstones. Login to comment 32 ABCG8 p.Asp19His We observed an association between risk variant ABCG8-D19H and post-surgery gallstone disease with a similar allelic odds ratio as for pre-cholecystectomy populations, thereby confirming the central pathophysiological role of this locus in the formation of gallstones. Login to comment 68 ABCG8 p.Asp19His An allele-based test of association was performed between rs11887534 (ABCG8-D19H) and gallstone recurrence, which yielded a p value of 0.034 in a two-sided Fisher exact test and an allelic odds ratio of 1.97 (95 % CI 1.12-?). Login to comment 69 ABCG8 p.Asp19His An allele-based test of association was performed between rs11887534 (ABCG8-D19H) and gallstone recurrence, which yielded a p value of 0.034 in a two-sided Fisher exact test and an allelic odds ratio of 1.97 (95 % CI 1.12-?). Login to comment 75 ABCG8 p.Asp19His In a logistic regression analyses including all clinical variables except scheduling and type of surgery, only the ABCG8-D19H genotype remained a significant predictor of gallstone recurrence (likelihood ratio test p = 0.024). Login to comment 76 ABCG8 p.Asp19His ABCG8 p.Asp19His When repeated including only those 1,650 patients for whom the type and scheduling of surgery was available, logistic regression analysis revealed both ABCG8-D19H (p = 0.020) and the type of surgery (p = 0.0035) as significant influential variables, thereby confirming that rs11887534 is an independent predictor of gallstone recurrence irrespective of the type of surgery. Login to comment 77 ABCG8 p.Asp19His ABCG8 p.Asp19His Discussion We have shown that ABCG8-D19H is a predictor of gallstone recurrence after cholecystectomy. Login to comment 78 ABCG8 p.Asp19His Discussion We have shown that ABCG8-D19H is a predictor of gallstone recurrence after cholecystectomy. Login to comment 93 ABCG8 p.Asp19His This notwithstanding, Table 1 Analysis of rs11887534 (ABCG8-D19H) as a predictor of gallstone recurrence after cholecystectomy The significance of the allelic genotype-phenotype association was assessed using Fisher`s exact test. Login to comment 94 ABCG8 p.Asp19His This notwithstanding, Table 1 Analysis of rs11887534 (ABCG8-D19H) as a predictor of gallstone recurrence after cholecystectomy The significance of the allelic genotype-phenotype association was assessed using Fisher`s exact test. Login to comment 96 ABCG8 p.Asp19His ABCG8 p.Asp19His %) Laparoscopic surgery 25 (1.7 %) 1,477 (98.3 %) 0.007 ABCG8-D19H could be identified as a risk factor because the corresponding effect size was comparatively large for a complex trait. Login to comment 100 ABCG8 p.Asp19His Importantly, ABCG8-D19H remained a statistically significant predictor of gallstone recurrence even if the type of surgery is adjusted for, despite the reduced number of individuals available for analysis (N = 1,650 vs. N = 1,908). Login to comment 103 ABCG8 p.Asp19His In addition, the association between ABCG8-D19H genotype and post-surgery gallstone recurrence underlines the central role of the sterolin transporters in the pathogenesis of gallstone disease, thereby furthering our understanding of the etiology of this disorder. Login to comment