ABCMdb

PMID: 22761669

Yin JY, Huang Q, Zhao YC, Zhou HH, Liu ZQ
Meta-analysis on pharmacogenetics of platinum-based chemotherapy in non small cell lung cancer (NSCLC) patients.
PLoS One. 2012;7(6):e38150. Epub 2012 Jun 26., [PubMed]

Sentences

No. Mutations Sentence Comment

4 ABCB1 p.Ala313Gly MDR1 C3435T (OR = 1.97, 95% CI: 1.11-3.50, P = 0.02), G2677A/T (OR = 2.61, 95% CI: 1.44-4.74, P = 0.002) and GSTP1 A313G (OR = 0.32, 95% CI: 0.17-0.58, P = 0.0002) were significantly correlated with platinum-based chemotherapy in Asian NSCLC patients. Login to comment 5 ABCB1 p.Ala313Gly Conclusion: Attention should be paid to MDR1 C3435T, G2677A/T and GSTP1 A313G for personalized chemotherapy treatment for NSCLC patients in Asian population in the future. Login to comment 23 ABCB1 p.Ala313Gly The same situation exists for GSTP1 A313G [9-11]. Login to comment 96 ABCB1 p.Ala313Gly Genes Polymorphisms NCBI SNP ID Allele Responders Non-responders References ERCC1 C354T rs11615 C 210 285 [6-8,22,59-64] (Asn118Asn) T 199 308 C8092A rs3212986 C 85 87 [9,22,65] A 85 93 XPD G934A rs1799793 G 114 174 [7-9,59,63,66-68] (Asp312Asn) A 93 181 A2251C rs13181 A 259 528 [7-9,59,63,65-70] (Lys751Gln) C 172 372 XPG T138C rs1047768 C 13 20 [23,24] (His46His) T 41 131 XRCC1 G1196A rs25487 G 60 110 [9,23,68,69] (Arg399Gln) A 71 152 MDR1 C3435T rs1045642 C 49 46 [8,32,60,63,71] (Ile1145Ile) T 88 141 G2677T/A rs2032582 G 31 22 [32,60,71] (Ala893Ser/Thr) T/A 44 67 GSTP1 A313G rs1695 A 64 181 [9-11,72] (Ile105Val) G 67 113 GSTM1 Deletion NR presence 31 63 [9,62] deletion 38 40 RRM1 C-37A NR C 87 123 [8,36,63] A 65 92 NR: not reported. Login to comment 137 ABCB1 p.Ala313Gly ABCB1 p.Ala313Gly ABCB1 p.Ala313Gly Authors Year Ethnicity (Country) Number of patients Disease stageGenotyping method Chemotherapeutic drugs Genes and polymorphism Reference Camps et al. 2003 Caucasian (Spain) 38 IIIB-IV Direct sequencing Cisplatin/Gemcitabine XPD: G934A XPD: A2251C [67] Isla et al. 2004 Caucasian (Spain) 62 IIIB-IV TaqMan genotyping assay Cisplatin/Docetaxel ERCC1: C354T MDR1: C3435T RRM1: A-37C XPD: G934A XPD: A2251C [8] Ryu et al. 2004 Asian (Korea) 108 IIIB-IV SNaPShot assay Platinum-based chemotherapy ERCC1: C354T XPD: G934A XPD: A2251C [59] Booten et al. 2006 Caucasian (UK) 89 III-IV Direct sequencing Platinum-based chemotherapy GSTP1:A313G [11] Booton et al. 2006 Caucasian (UK) 89 III-IV PCR-RFLP Direct sequencing Platinum-based chemotherapy XPD: G934A XPD: A2251C [66] Su et al. 2007 Asian (China) 76 IIIA-IV TaqMan genotyping assay Platinum-based chemotherapy ERCC1: C354T [6] Giachino et al. 2007 Caucasian (Italy) 188 IIIA-IV PCR-RFLP Platinum-based chemotherapy XRCC1: G1196A XPD: A2251C [69] Tibaldi et al. 2008 Caucasian (Italy) 65 IIIB-IV TaqMan genotyping assay Cisplatin/Gemcitabine ERCC1: C354T XPD: G934A XPD: A2251C [7] Pan et al. 2008 Asian (China) 69 IIIB-IV PCR-RFLP Cisplatin/Vinorelbine MDR1: C3435T MDR1: G2677A/T [71] Yu et al. 2008 Asian (China) 117 NR Direct sequencing Carboplatin/Etoposide ERCC1: C354T ERCC1: C8092A [22] Kalikaki et al. 2009 Caucasian (Greece) 119 IIIA-IV PCR-RFLP Direct sequencing Platinum-based chemotherapy ERCC1: C354T ERCC1: C8092A GSTP1: A313G GSTM1: deletion XPD: G934A XPD: A2251C XRCC1: G1196A [9] Feng et al. 2009 Asian (China) 214 IIB-IV PCR-RFLP Platinum-based chemotherapy RRM1: A-37C [36] Yao et al. 2009 Asian (China) 102 IIIB-IV PCR-RFLP Platinum-based chemotherapy XRCC1: G1196A [68] Sun et al. 2009 Asian (China) 90 IV 3-D polyacrylamide gel-based DNA microarray Platinum-based chemotherapy XRCC1: G1196A [23] Pan et al. 2009 Asian (China) 54 IIIB-IV PCR-RFLP Cisplatin/Docetaxel MDR1: C3435T MDR1: G2677A/T [32] Zhou et al. 2010 Asian (China) 130 IIIB-IV TaqMan genotyping assay Platinum-based chemotherapy ERCC1: C354T [61] Chen et al. 2010 Asian (China) 95 IIIB-IV Ligase detection reactions (LDR) Platinum-based chemotherapy ERCC1: C354T MDR1: C3435T MDR1: G2677A/T [60] Sun et al. 2010 Asian (China) 113 IIIA-IV 3-D polyacrylamide gel-based DNA microarray Platinum-based chemotherapy GSTP1: A313G [10] Li et al. 2010 Asian (China) 115 IIIB-IV 3-D polyacrylamide gel-based DNA microarray Platinum-based chemotherapy ERCC1: C354T XPD: A2251C [65] Vinolas et al. 2011 Caucasian (Spain) 94 IIIB-IV 59 nuclease allelic discrimination assay Cisplatin/Vinorelbine ERCC1: C354T XPD: G934A XPD: A2251C MDR1: C3435T RRM1: A-37C [63] Zhou et al. 2011 Asian (China) 111 IV Direct sequencing Platinum-based chemotherapy GSTP1: A313G [72] Li et al. 2012 Asian (China) 58 NR PCR-RFLP Platinum-based chemotherapy GSTM1:deletion [62] Chen et al. 2012 Asian (China) 355 IIIB-IV TaqMan genotyping assay Platinum-based chemotherapy XPD: A2251C [70] Cheng et al. 2012 Asian (China) 142 IIIB-IV Direct sequencing Platinum-based chemotherapy ERCC1: C354T [64] NR: not reported. Login to comment 143 ABCB1 p.Ala313Gly GSTP1 A313G was the most widely studied polymorphism. Login to comment 144 ABCB1 p.Ala313Gly GSTP1 A313G was the most widely studied polymorphism. Login to comment 148 ABCB1 p.Ala313Gly The result showed no association between GSTP1 A313G and platinum-based chemotherapy (OR = 0.61, 95% CI: 0.2921.28, P = 0.19) (Figure 6A). Login to comment 149 ABCB1 p.Ala313Gly The result showed no association between GSTP1 A313G and platinum-based chemotherapy (OR = 0.61, 95% CI: 0.2921.28, P = 0.19) (Figure 6A). Login to comment 156 ABCB1 p.Ala313Gly As showed in Figure 6 B and C, GSTP1 A313G was only significantly associated with drug response in Asian population. Login to comment 157 ABCB1 p.Ala313Gly As showed in Figure 6 B and C, GSTP1 A313G was only significantly associated with drug response in Asian population. Login to comment 167 ABCB1 p.Ala313Gly The results showed that MDR1 C3435T, G2677A/T and GSTP1 A313G were significantly correlated with platinum-based chemotherapy in the Asian NSCLC patients. Login to comment 168 ABCB1 p.Ala313Gly The results showed that MDR1 C3435T, G2677A/T and GSTP1 A313G were significantly correlated with platinum-based chemotherapy in the Asian NSCLC patients. Login to comment 187 ABCB1 p.Ala313Gly Another polymorphism found to be significantly correlated with drug response was GSTP1 A313G, which is a non-synonymous SNP located in exon 5 [33]. Login to comment 188 ABCB1 p.Ala313Gly Another polymorphism found to be significantly correlated with drug response was GSTP1 A313G, which is a non-synonymous SNP located in exon 5 [33]. Login to comment 190 ABCB1 p.Ala313Gly Previous study showed that GSTP1 A313G resulted in reduced glutathione conjugating ability [33]. Login to comment 191 ABCB1 p.Ala313Gly Previous study showed that GSTP1 A313G resulted in reduced glutathione conjugating ability [33]. Login to comment 210 ABCB1 p.Ala313Gly Meta-analysis of association between GSTP1 A313G and platinum-based chemotherapy in overall (A), Asian (B) and Caucasian (C) NSCLC patients. Login to comment 211 ABCB1 p.Ala313Gly Meta-analysis of association between GSTP1 A313G and platinum-based chemotherapy in overall (A), Asian (B) and Caucasian (C) NSCLC patients. Login to comment 223 ABCB1 p.Ala313Gly Although most of the separately analyzed results were consistent with overall population, two polymorphisms (MDR1 C3435T and GSTP1 A313G) showed ethnic difference. Login to comment 224 ABCB1 p.Ala313Gly Although most of the separately analyzed results were consistent with overall population, two polymorphisms (MDR1 C3435T and GSTP1 A313G) showed ethnic difference. Login to comment 276 ABCB1 p.Ala313Gly In conclusion, we identified that MDR1 C3435T, G2677A/T and GSTP1 A313G were significantly correlated with platinum-based chemotherapy in Asian NSCLC patients. Login to comment 277 ABCB1 p.Ala313Gly In conclusion, we identified that MDR1 C3435T, G2677A/T and GSTP1 A313G were significantly correlated with platinum-based chemotherapy in Asian NSCLC patients. Login to comment