PMID: 22701530

Coppinger JA, Hutt DM, Razvi A, Koulov AV, Pankow S, Yates JR 3rd, Balch WE
A chaperone trap contributes to the onset of cystic fibrosis.
PLoS One. 2012;7(5):e37682. doi: 10.1371/journal.pone.0037682. Epub 2012 May 31., [PubMed]
Sentences
No. Mutations Sentence Comment
147 ABCC7 p.Ile539Thr
X
ABCC7 p.Ile539Thr 22701530:147:71
status: NEW
view ABCC7 p.Ile539Thr details
 This stable core structure is never achieved in DF508-NBD1, unless the I539T and/or other suppressor mutations are introduced [20,21,23,29,30]. Login to comment 148 ABCC7 p.Ile539Thr
X
ABCC7 p.Ile539Thr 22701530:148:99
status: NEW
view ABCC7 p.Ile539Thr details
 Interestingly, peptide 4 spans residues 525-532 of NBD1, which places it in close proximity to the I539T mutation and within the stable core of the WT protein. Login to comment 149 ABCC7 p.Ile539Thr
X
ABCC7 p.Ile539Thr 22701530:149:71
status: NEW
view ABCC7 p.Ile539Thr details
 This stable core structure is never achieved in DF508-NBD1, unless the I539T and/or other suppressor mutations are introduced [20,21,23,29,30]. Login to comment 150 ABCC7 p.Ile539Thr
X
ABCC7 p.Ile539Thr 22701530:150:99
status: NEW
view ABCC7 p.Ile539Thr details
 Interestingly, peptide 4 spans residues 525-532 of NBD1, which places it in close proximity to the I539T mutation and within the stable core of the WT protein. Login to comment 229 ABCC7 p.Phe494Asn
X
ABCC7 p.Phe494Asn 22701530:229:8
status: NEW
view ABCC7 p.Phe494Asn details
 NBD1-WT(F494N)-TTEVVMENVTAFWEEGFGELFE- KAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINF- KIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS- GRISFCSQNSWIMPGTIKENIIFGVSYDEYRYRSVIKACQ- LEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYK- DADLYLLDSPFGYLDVLTEKEIFESCVCKLMANK- TRILVTSKMEHLKKADKILILHEGSSYFYGTF- SELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRF- SLEGDAPVS. Login to comment 230 ABCC7 p.Phe494Asn
X
ABCC7 p.Phe494Asn 22701530:230:12
status: NEW
view ABCC7 p.Phe494Asn details
 NBD1-DF508 (F494N)-TTEVVMENVTAFWEEGFGELFE- KAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINF- KIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS- GRISFCSQNSWIMPGTIKENIIGVSYDEYRYRSVIKACQ- LEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYK- DADLYLLDSPFGYLDVLTEKEIFESCVCKLMANK- TRILVTSKMEHLKKADKILILHEGSSYFYGTF- SELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRF- SLEGDAPVS. Login to comment 233 ABCC7 p.Phe494Asn
X
ABCC7 p.Phe494Asn 22701530:233:8
status: NEW
view ABCC7 p.Phe494Asn details
 NBD1-WT(F494N)-TTEVVMENVTAFWEEGFGELFE- KAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINF- KIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS- GRISFCSQNSWIMPGTIKENIIFGVSYDEYRYRSVIKACQ- LEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYK- DADLYLLDSPFGYLDVLTEKEIFESCVCKLMANK- TRILVTSKMEHLKKADKILILHEGSSYFYGTF- SELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRF- SLEGDAPVS. Login to comment 234 ABCC7 p.Phe494Asn
X
ABCC7 p.Phe494Asn 22701530:234:12
status: NEW
view ABCC7 p.Phe494Asn details
 NBD1-DF508 (F494N)-TTEVVMENVTAFWEEGFGELFE- KAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINF- KIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS- GRISFCSQNSWIMPGTIKENIIGVSYDEYRYRSVIKACQ- LEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYK- DADLYLLDSPFGYLDVLTEKEIFESCVCKLMANK- TRILVTSKMEHLKKADKILILHEGSSYFYGTF- SELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRF- SLEGDAPVS. Login to comment