ABCMdb

PMID: 22688145

Parkman HP, Mishra A, Jacobs M, Pathikonda M, Sachdeva P, Gaughan J, Krynetskiy E
Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters.
J Clin Gastroenterol. 2012 Jul;46(6):494-503. doi: 10.1097/MCG.0b013e3182522624., [PubMed]

Sentences

No. Mutations Sentence Comment

87 ABCB1 p.Asn21Asp SNPs Evaluated in This Study With Corresponding Genes and Functional Consequences of Polymorphisms Genes/Alleles SNP Markers Function Effect of Genetic Polymorphism CYP2D6 rs1080985 Oxidative metabolism SNP in intron Phenotype-associated allele CYP2D6 rs16947 Oxidative metabolism Cys245Arg Phenotype-associated allele CYP2D6 rs3892097 Oxidative metabolism SNP in intron Loss of function CYP1A2 rs2069514 Oxidative metabolism Upstream region Phenotype-associated allele CYP1A2 rs762551 Oxidative metabolism Upstream region Phenotype-associated allele DRD3 rs7625282 Dopamine receptor Intron DRD2 rs1799978 Dopamine receptor Upstream region Phenotype-associated allele DRD2 rs6275 Dopamine receptor His313His Phenotype-associated allele DRD2 rs6277 Dopamine receptor Pro319Pro Phenotype-associated allele ABCB1 rs1045642 Drug transporter Ile1145Ile Decreased function ABCB1 rs9282564 Drug transporter Asn21Asp Decreased function HTR4 rs10078551 Serotonin receptor 4 Forms a haplotype HTR4 rs7713886 Serotonin receptor 4 Forms a haplotype HTR4 rs7735184 Serotonin receptor 4 SNP in intron HTR4 rs9325104 Serotonin receptor 4 SNP in intron KCNH2 rs1805123 Potassium voltage-gated channel H (eag-related), member 2 K897T Phenotype-associated allele KCNH2 rs3807375 Potassium voltage-gated channel H (eag-related), member 2 Phenotype-associated allele (QT prolongation) KCNH2 rs3815459 Potassium voltage-gated channel H (eag-related), member 2 SNP in intron Phenotype-associated allele (QT interval) ADRA1D rs2236554 Adrenergic receptor a1D 30 -UTR ADRA1D rs709024 Adrenergic receptor a1D 30 -UTR SNP indicates single nucleotide polymorphism. Login to comment