PMID: 22587419

Mandal A, Kumar A, Singh A, Lynn AM, Kapoor K, Prasad R
A key structural domain of the Candida albicans Mdr1 protein.
Biochem J. 2012 Aug 1;445(3):313-22., [PubMed]
Sentences
No. Mutations Sentence Comment
134 ABCB1 p.Glu325Ala
X
ABCB1 p.Glu325Ala 22587419:134:369
status: NEW
view ABCB1 p.Glu325Ala details
 The majority of the charged amino acids of ICL3 are functionally critical A close examination of the ICL3 sequence reveals that the positively charged amino acid residues, i.e. K301A, R306A, K307A, K309A, R310A, R312A, R319A, K330A and H334A, are mostly confined to the N-terminal half of the loop, whereas the negatively charged amino acids, i.e. E297A, D318A, E323A, E325A, E327A, E335A, D339A, E346A and E351A, are predominantly clustered towards the C-terminal half (Figure 1 and Supplementary Figure S2C). Login to comment