PMID: 22170719

Chen H, Guo JH, Lu YC, Ding GL, Yu MK, Tsang LL, Fok KL, Liu XM, Zhang XH, Chung YW, Huang P, Huang H, Chan HC
Impaired CFTR-dependent amplification of FSH-stimulated estrogen production in cystic fibrosis and PCOS.
J Clin Endocrinol Metab. 2012 Mar;97(3):923-32. Epub 2011 Dec 14., [PubMed]
Sentences
No. Mutations Sentence Comment
19 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 22170719:19:66
status: NEW
view ABCC7 p.Ser489* details
 In line with the observation in CF patients, CF mouse models with S489X (17) and DF508 mutation (18) in CFTR also display ovarian disorders with delayed puberty, reduced ovarian size and weight, decreased ovulated oocyte number, longer estrous cycle length, or even the absence of estrous cycle (19). Login to comment 23 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 22170719:23:91
status: NEW
view ABCC7 p.Ser489* details
 Materials and Methods Animals Female ICR (Institute for Cancer Research) mice, cftrtm1Unc (S489X) mice (17), cftrtm1Kth (DF508) mice (18), and Sprague-Dawley (SD) rats were maintained in the Laboratory Animal Service Center, the Chinese University of Hong Kong. Login to comment 146 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 22170719:146:103
status: NEW
view ABCC7 p.Ser489* details
 A, Immunofluorescent staining of CREB and phospho-CREB in wild-type (WT) and homozygous CFTR knockout (S489X) mice ovaries. Login to comment 183 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 22170719:183:104
status: NEW
view ABCC7 p.Ser489* details
 The expression levels of CREB and phospho-CREB were reduced in the ovaries of homozygous CFTR knockout (S489X) mice compared with the wild-type control, as shown by immunofluorescent staining (Fig. 4A), suggesting that the cAMP-CREB signaling pathway is impaired in CFTR knockout mice. Login to comment