PMID: 22086859

Mint Lekweiry K, Ould Mohamed Salem Boukhary A, Gaillard T, Wurtz N, Bogreau H, Hafid JE, Trape JF, Bouchiba H, Ould Ahmedou Salem MS, Pradines B, Rogier C, Basco LK, Briolant S
Molecular surveillance of drug-resistant Plasmodium vivax using pvdhfr, pvdhps and pvmdr1 markers in Nouakchott, Mauritania.
J Antimicrob Chemother. 2012 Feb;67(2):367-74. Epub 2011 Nov 14., [PubMed]
Sentences
No. Mutations Sentence Comment
78 ABCC8 p.Ala553Gly
X
ABCC8 p.Ala553Gly 22086859:78:161
status: NEW
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 The key pfdhps codon mutations that are associated with sulfadoxine resistance (S436A/F, A437G, K540E, A581G and A613S) correspond to S382A/C, A383G, K512M/T/E, A553G/C and V585, respectively, in pvdhps.33 So far, only V585 has been observed. Login to comment 96 ABCC8 p.Cys170*
X
ABCC8 p.Cys170* 22086859:96:233
status: NEW
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 Five mutations were synonymous (A45G, T114C, T207C, C360T and C493T in the nucleotide sequence) and four mutations were non-synonymous: G190A, G229C, A361T and C510A in the nucleotide sequence, corresponding to V64M, E77Q, I121F and C170stop in the amino acid sequence, respectively. Login to comment 101 ABCC8 p.Gly505Arg
X
ABCC8 p.Gly505Arg 22086859:101:208
status: NEW
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 Five novel mutations were found in five different isolates at positions 388, 400, 455, 505 and 550 (C1163T, C1199T, A1363G, G1513A and T1649C in the nucleotide sequence, corresponding to P388L, P400L, T455A, G505R and L550P in the amino acid sequence, respectively). Login to comment 125 ABCB1 p.Ala361Thr
X
ABCB1 p.Ala361Thr 22086859:125:65
status: NEW
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ABCB1 p.Ile121Phe
X
ABCB1 p.Ile121Phe 22086859:125:72
status: NEW
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 of isolates C174A (S58R) G190A (V64M) G229C (E77Q) G350A (S117N) A361T (I121F) C2873T (T958M) A2927T (Y976F) T3226C (F1076L) C G G G A T A C 1 39 NA NA NA NA NA T A C 1 13 C G G G A T T C 1 12 C G C G A T A C 1 5 NA NA NA NA NA T T C 1 5 C G C G A T T C 1 4 C G G G A NA NA NA 1 4 A G G A A T A C 1 3 C G G G A C A C 1 3 C G G G A T A C 2 2 C G G G A T A T 1 2 NA NA NA NA NA C A C 1 2 A/C G G A/G A T A C 1 2 A G G A A C A C 1 1 A G G A A C T C NA 1 A G G A/G A T T C 1 1 C G G G A NA NA NA NA 1 C G G NA NA T T C 1 1 NA NA NA NA NA T A C NA 1 NA NA NA NA NA T T C 2 1 A G G A A T T C 1 1 A G G A T T A C 1 1 C A G G A T A C 1 1 C G C G A C T C 1 1 C G G G A C T C 1 1 NA NA NA NA NA NA NA NA NA 2 NA, not available. Login to comment 129 ABCC8 p.Gly505Arg
X
ABCC8 p.Gly505Arg 22086859:129:92
status: NEW
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ABCB1 p.Ile121Phe
X
ABCB1 p.Ile121Phe 22086859:129:54
status: NEW
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 Novel non-synonymous mutations include V64M, E77Q and I121F in pvdhfr; P388L, P400L, T455A, G505R and L550P in pvdhps in five different isolates; and T958M in pvmdr1. Login to comment