PMID: 22064972

Zhao GJ, Yin K, Fu YC, Tang CK
The interaction of ApoA-I and ABCA1 triggers signal transduction pathways to mediate efflux of cellular lipids.
Mol Med. 2012 Mar 27;18(1):149-58. doi: 10.2119/molmed.2011.00183., [PubMed]
Sentences
No. Mutations Sentence Comment
43 ABCA1 p.Trp590Ser
X
ABCA1 p.Trp590Ser 22064972:43:32
status: NEW
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 ApoA-I failed to increase ABCA1-W590S levels in these studies, suggesting that apoA-I binding was not sufficient for ABCA1 stabilization (36). Login to comment 45 ABCA1 p.Trp590Ser
X
ABCA1 p.Trp590Ser 22064972:45:56
status: NEW
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 Another interpretation is that apoA-I fails to bind the W590S mutant in the correct orientation, and therefore the appropriate conformational change of ABCA1 required to decrease calpain proteolysis does not occur. Login to comment 194 ABCA1 p.Trp590Ser
X
ABCA1 p.Trp590Ser 22064972:194:122
status: NEW
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 This appears to be a necessary, but not sufficient, step for lipid efflux (88), because, in the case of the ABCA1 mutant (Trp590Ser) that is associated with Tangier disease, an apoA-I/ABCA1 complex also is formed, but the apoA-I is not lipidated (15). Login to comment