PMID: 22056837

Saint-Criq V, Ruffin M, Rebeyrol C, Guillot L, Jacquot J, Clement A, Tabary O
Azithromycin fails to reduce inflammation in cystic fibrosis airway epithelial cells.
Eur J Pharmacol. 2012 Jan 5;674(1):1-6. doi: 10.1016/j.ejphar.2011.10.027. Epub 2011 Oct 26., [PubMed]
Sentences
No. Mutations Sentence Comment
33 ABCC7 p.Trp1282*
X
ABCC7 p.Trp1282* 22056837:33:109
status: NEW
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 Cell culture IB3-1 is a bronchial epithelial cell line derived from a cystic fibrosis patient with a F508del/W1282X CFTR genotype. Login to comment 51 ABCC8 p.Ile152Leu
X
ABCC8 p.Ile152Leu 22056837:51:64
status: NEW
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 Iodide rather than chloride is used because of strong YFP-H148Q/I152L quenching by iodide, and because CFTR is permeable to iodide (Verkman and Galietta, 2009). Login to comment 107 ABCC8 p.Ile152Leu
X
ABCC8 p.Ile152Leu 22056837:107:93
status: NEW
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 CFTR activities were determined by CFTR halide conductance in cells expressing an YFP-H148Q/ I152L/F46L indicator stimulated by CFTR agonist mixture of CFTR. Login to comment